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    DETROL LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, week study. The effect of a mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were CYP2D6 poor metabolizers.

    Potent CYP3A4 inhibitors: In vitro data show that tolterodine immediate release is a competitive inhibitor of CYP2D6 at high concentrations Ki 1.

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    The effect of a mg daily dose of ketoconazole detrol la indications the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were CYP2D6 poor metabolizers. In a study to assess the effect of fluoxetine on the pharmacokinetics of tolterodine immediate release and its metabolites, it was observed that fluoxetine significantly inhibited the metabolism of tolterodine immediate release in extensive metabolizers, resulting in a 4.

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    • DETROL LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, week study
    • In the presence of ketoconazole, the mean Cmax and AUC of tolterodine increased by 2- and 2
    • DETROL LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, week study

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    In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole.

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    In healthy volunteers, coadministration of tolterodine immediate release 4 mg 2 mg bid for 7 days and a single dose of warfarin detrol la indications mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin.

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    Detrol la indications

    In the presence of ketoconazole, the mean Cmax and AUC of tolterodine increased by 2- and 2. Based on these findings, other potent CYP3A4 inhibitors may also lead to increases of tolterodine plasma concentrations.

    No dose adjustment is required when tolterodine and fluoxetine are co-administered.

    Fluoxetine is a selective serotonin reuptake inhibitor detrol la indications a potent inhibitor of CYP2D6 activity. Potent CYP2D6 inhibitors: Secondary efficacy measures included change in mean number of micturitions per day and mean volume voided per micturition at week 12 from baseline or . No mutagenic zithromax azithromycin 200mg 5ml genotoxic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays Ames test in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in LY mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes.

    The effect of a mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were CYP2D6 poor metabolizers. Fluoxetine thus alters the pharmacokinetics in patients who would otherwise be CYP2D6 extensive metabolizers of tolterodine immediate release to resemble the pharmacokinetic profile in poor metabolizers.

    Nolvadex 20 dose adjustment is required when tolterodine and detrol la indications are co-administered. Fluoxetine thus alters the pharmacokinetics in patients who would otherwise be CYP2D6 extensive metabolizers of tolterodine immediate release to resemble detrol la indications pharmacokinetic profile in poor metabolizers.

    Potent CYP3A4 inhibitors: Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse.

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    Comment №1 about product

    The primary efficacy assessment was change in mean number of incontinence episodes per week at week 12 from baseline. Fluoxetine is a selective serotonin reuptake inhibitor and a potent inhibitor of CYP2D6 activity, coffee-mind.com.


    4 / 5 stars
    Comment №2 about product

    Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug-metabolizing CYP enzymes.


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