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PPIs, which include brand names such as Prilosec, Nexium and Prevacid, are among the most commonly prescribed medications in the world, particularly among people with chronic liver disease. They found that increased Enterococcus alone was sufficient to induce mild steatosis and increase alcohol-induced liver disease in mice.
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These changes promoted liver inflammation and liver injury, increasing the progression of all three types of liver disease in the mice: Hepatology ; Br J Clin Pharmacol ; They also reported that the rate of liver disease in people who chronically abuse alcohol was 8.
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They analyzed a cohort of 4, patients with a diagnosis of chronic alcohol abuse — 1, 21 percent were active PPI users, 15 percent were previous users and 63 percent had never used PPIs. The researchers next investigated whether there might be a link between PPIs and the development of alcoholic liver disease. One study suggests that PPI prescriptions in the United States are on the risedespite the fact that they are tied to a series of adverse events.
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