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Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
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Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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This complex then binds to DNA and induces the expression of genes promoting cell growth and proliferation. Molecular genetics tests may be very useful in determining colo-rectal neoplastic mutations and in guiding patients and their relatives There are currently three known PPAR receptor isoforms, called a, d and g 13,30, FitzGerald GA - Parsing an enigma:

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Prostaglandins are gastric mucosa vasodilators and seem to be involved with local blood flow regulation. In fact, adverse gastrointestinal NSAIDs effects are associated to the suppression of COX-1 constitutive expression, resulting in gastric damage, hemorrhage and ulceration 13,45, The discovery of COX-2 has enabled the development of more selective drugs to decrease inflammation without affecting COX-1 that protects stomach and kidneys and giving origin to a new generation of anti-inflammatory compounds called specific COX-2 inhibitors.

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